Our Force Measurement Service Capabilities

Modern drug products rely on precise mechanical performance to ensure safe, predictable delivery. Small variations in activation force, plunger travel, seal strength, or closure behavior can affect dose accuracy, usability, stability, and ultimately regulatory approval. nuvalore provides pharmaceutical teams with precise, GMP-compliant mechanical testing that reveals risks early and verifies that every component behaves as intended.

Our Force Measurement Services span the full range of syringe, autoinjector, container closure, and packaging evaluations required for today’s combination products. Every test is executed under GMP using validated equipment and ISO-aligned methods, so development teams receive data they can trust for decision-making, troubleshooting, and submission readiness.

Prefilled Syringe Testing (Break-Loose & Glide Force)

As part of our Force Measurement Services, one of our core capabilities is measuring the forces required to move syringe plungers. We determine the break-loose force (the initial force to start movement) and the glide force (the force required to maintain movement) for prefilled syringes. These forces must remain within a tight range — too high and the syringe becomes difficult to inject; too low and it may indicate leakage or plunger defects. By rigorously testing to ISO standards, we ensure every batch delivers smooth, controlled plunger motion that supports reliable, patient-friendly injections.

Benefit: Provides consistent plunger performance with no jams, stalls, or leaks.

Autoinjectors & Pens Testing – Full Function Verification

For spring-driven autoinjectors and pen injectors, we perform complete force-profile analysis as part of our Drug Delivery Device Testing Services. Using specialized fixtures, our team simulates the full injection event — triggering the device and recording activation force, spring deployment, and the injection force-time curve. These assessments verify that the device activates the correct force, deploys smoothly, and delivers the medication as intended. All autoinjector testing is aligned with ISO expectations for Combination Product Testing, ensuring reliable performance and patient safety.

Benefit: Provides clear mechanical evidence that each device activates smoothly and delivers the intended dose.

Container Closures Testing – Tight but Usable

We evaluate the mechanical performance of vial stoppers, bottle caps, syringe needle shields, and other components that seal a pharmaceutical container. Our testing includes needle penetration force—too much force may damage the needle or complicate use; too little may compromise seal integrity. We also measure cap removal and shield pull-off forces to confirm closures are secure enough to protect the product yet not so tight that patients struggle to open them. Our closure testing ensures containers remain leak-proof, user-friendly, and aligned with pharmaceutical expectations.

Benefit: Ensures closures protect the product while remaining easy for patients to access.

Packaging & Blister Pack Strength Testing

Packaging plays a critical role in product protection and patient usability. We use force-based methods to evaluate blister packs, foil seals, and pouches through tensile, peel, and seal-strength measurements. These tests confirm that packaging withstands shipping and handling while still peeling open smoothly for patients. If seals are too weak, the product risks contamination; if too strong, patients may struggle to access their medication. By validating packaging against ASTM standards, we ensure every unit is properly protected and practical for patients.

Benefit: Packaging remains intact during distribution yet opens smoothly for patients—reducing complaints and product failures.

Product Types We Support

nuvalore supports a wide range of drug delivery and packaging systems across clinical and commercial development.

• Prefilled syringes (glass & polymer)
• Combination products, including biologics
• Autoinjectors, pen injectors, emergency injectors
• Vial systems, stoppers, caps, needle shields
• Blister packs, foil seals, and pouches
• Packaging components for clinical and commercial phases

Why Companies Choose Nuvalore

nuvalore specializes in GMP-compliant mechanical testing for drug delivery and combination products. We provide the precision, traceability, and clarity development teams need to make confident decisions.

What You Receive with Every Force Measurement Study:

• GMP execution with validated equipment and full audit trails
• ISO/ASTM-aligned methods for syringes, autoinjectors, closures, and packaging
• Clear force outputs: force-time/force-displacement curves and key activation metrics
• Regulatory-ready reports with statistics, lot comparisons, and pass/fail results
• Complete documentation – methods, raw data, and electronic signatures
• Device expertise across prefilled syringes, autoinjectors, pens, vials, and blister/foil formats
• Fast, predictable timelines with direct access to the scientists running your study

nuvalore delivers defensible mechanical data and clean documentation — so you can verify device performance, avoid late-stage surprises, and move through development and submissions with confidence.